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Effect of increased water intake on plasma copeptin in healthy adults

Sammy Farag by Sammy Farag
July 26, 2017
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Last updated on April 14th, 2025 at 10:49 am

Published online: June 3 2017 European Journal of Nutrition (IF 3.239).  Guillaume Lemetais · Olle Melander · Mariacristina Vecchio · Jeanne H. Bottin ·
Sofa Enhörning · Erica T. Perrier

Abstract

PURPOSE:

Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin.

METHODS:

This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m2, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50-80% of EFSA dietary reference values), arm B (81-120%), and arm C (121-200%). Following a baseline visit, arms A and B increased their water intake to match arm C for a period of 6 consecutive weeks.

RESULTS:

At baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p < 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p < 0.001), respectively.

CONCLUSIONS:

At baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT02044679.

KEYWORDS:

Copeptin; Fluid intake; Hydration; Urine osmolality; Water intake

Effect of increased water intake on plasma copeptin in healthy adults

 

The post Effect of increased water intake on plasma copeptin in healthy adults appeared first on Facts About Water.

Source: Water Feed

Tags: RO
Sammy Farag

Sammy Farag

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