Transformation Of Endocrine Disrupting Chemicals, Pharmaceutical

endocrine disrupting compounds, EDCs, show up in our drinking water sources all the time. That’s a real worry, especially because these chemicals might change into something even worse after water disinfection. So, we decided to look into the biological activity of eight common EDCs and PPCPs found in source water, both before and after disinfection. These included acetaminophen, bisphenol A, carbamazepine, estrone, 17 alpha-ahinylestradiol, gemfibrozil, naproxen, and triclosan.

The post appeared first on .

Source: Water Feed

Frequently Asked Questions

Does drinking water disinfection increase the toxicity of endocrine disrupting chemicals (EDCs) and pharmaceuticals?
The study found that while disinfection of EDCs and PPCPs produces a large number of transformation products (TPs), it is unlikely to increase specific toxicity like endocrine activity. However, it may lead to increased reactive and non-specific toxicity. This highlights the complex nature of disinfection byproducts in water treatment.

What are common endocrine disrupting chemicals (EDCs) and pharmaceuticals found in source water?
The study investigated eight common EDCs and PPCPs frequently detected in source waters, including acetaminophen, bisphenol A, carbamazepine, estrone, 17 alpha-ahinylestradiol, gemfibrozil, naproxen, and triclosan. These compounds originate from various human activities and waste streams, posing challenges for water purification.

How many transformation products are formed when EDCs and PPCPs are disinfected?
Using a Stepped Forced Molecular Dynamics (SFMD) method, the study detected 911 unique transformation products (TPs) resulting from the disinfection of EDCs and PPCPs. Notably, 36% of these TPs had been previously reported in scientific literature, indicating a significant and complex array of new compounds.

Which disinfectants were evaluated for their impact on EDCs and PPCPs?
The study performed batch experiments using three common disinfectants: chlorine, chlorine dioxide, and chloramine. These are widely utilized in municipal water treatment, and the research assessed their role in transforming endocrine disrupting chemicals and pharmaceuticals into various byproducts.

How was the potential toxicity of disinfection byproducts assessed in this study?
Researchers employed a combination of computational methods, including Quantitative Structure-Activity Relationship (QSAR) tools, and experimental techniques. This involved chemical analysis and a battery of eleven in vitro bioassays to cover various toxicity endpoints, providing a comprehensive assessment of the transformation products. AMPAC USA engineers leverage such scientific understanding to design robust water purification systems.