{"id":770,"date":"2017-12-20T15:19:48","date_gmt":"2017-12-20T15:19:48","guid":{"rendered":"https:\/\/www.ampac1.com\/blog\/applicability-of-the-direct-injection-liquid-chromatographic-tandem-mass-spectrometric-analytical-approach-to-the-sub-ng-l-1-determination-of-perfluoro-alkyl-acids-in-waste-surface-ground-and-drinki\/"},"modified":"2026-05-03T20:22:10","modified_gmt":"2026-05-04T03:22:10","slug":"applicability-of-the-direct-injection-liquid-chromatographic-tandem-mass-spectrometric-analytical-approach-to-the-sub-ng-l-1-determination-of-perfluoro-alkyl-acids-in-waste-surface-ground-and-drinki","status":"publish","type":"post","link":"https:\/\/www.ampac1.com\/blog\/applicability-of-the-direct-injection-liquid-chromatographic-tandem-mass-spectrometric-analytical-approach-to-the-sub-ng-l-1-determination-of-perfluoro-alkyl-acids-in-waste-surface-ground-and-drinki\/","title":{"rendered":"Applicability of the direct injection liquid chromatographic tandem mass spectrometric analytical approach to the sub-ng L-1 determination of perfluoro-alkyl acids in waste, surface, ground and drinking water samples"},"content":{"rendered":"

Quick Answer:<\/strong> To really measure per- and polyfluoroalkyl substances (PFAS) in drinking<\/a> water, you need super precise tools. These compounds are tricky because they show up in tiny amounts. That’s where direct injection liquid chromatography paired with tandem mass spectrometry (LC-MS\/MS) comes in, it’s the go-to method. And for cleaning water, advanced systems like reverse osmosis are your best bet. AMPAC USA builds commercial and industrial systems specifically for these water treatment challenges. Our systems deliver certified, documented performance.<\/p>\n

Author Full Names: Ciofi, Lorenzo; Renai, Lapo; Rossini, Daniele; Ancillotti, Claudia; Falai, Alida; Fibbi, Donatella; Bruzzoniti, Maria Concetta; Juan Santana-Rodriguez, Jose; Orlandini, Serena; Del Bubba, Massimo
\nSource:
\nLanguage: English<\/p>\n

Abstract: We looked at how well a direct injection UHPLC-MS\/MS method could analyze several perfluoroalkyl acids (PFAAs) in all sorts of water. The method’s simple: just inject 100 \u00b5L of centrifuged water, no other steps needed. We got really good detection limits, from 0.014-0.44 \u00b5g L-1, and excellent precision, with RSD% values between 1.8-4.4% for within-day tests and 2.7-5.7% for between-day tests. The whole analysis takes just 20 minutes per sample. We ran a lot of samples: 8 drinking waters (DW), 12 ground waters (GW), 13 surface waters (SW), 8 influents and 11 effluents from wastewater treatment plants (WWTPIN and WWTPOUT). We calculated the matrix effect (ME) for each, and most showed a small effect, less than 20%. Occasionally, we saw a bigger effect, over 50%, but only for perfluorooctanesulphonic and perfluorodecanoic acids. Linear discriminant analysis showed that where the sample came from \u2013 like drinking water, ground water, surface water, or wastewater plant influent and effluent \u2013 really influenced the matrix effect. We also used partial least square regression (PLS) and leave-one-out cross-validation to try and figure out why signals were suppressed or enhanced. We checked this against water parameters like conductivity, hardness, chemical oxygen demand, and background chromatographic area. The PLS approach gave us a rough idea, but its prediction power wasn’t super strong. Still, for most analytes in most samples, the values helped us tell if the matrix effect was higher or lower than 20%. We quantified PFAAs in all those water samples using the standard addition method. It turns out they’re mostly in wastewater treatment plant influents and effluents, sometimes at concentrations as high as one hundred \u00b5g L-1.<\/p>\n

The post appeared first on .<\/p>\n

Source: Water Feed<\/p>\n","protected":false},"excerpt":{"rendered":"

The applicability of a direct injection UHPLC-MS\/MS method for the analysis of several perfluoroalkyl acids (PFAAs) in a wide range of water matrices was investigated.<\/p>\n","protected":false},"author":1,"featured_media":88005,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[24,29],"tags":[22],"class_list":["post-770","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-water-filter","category-water-treatment","tag-ro"],"_links":{"self":[{"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/posts\/770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/comments?post=770"}],"version-history":[{"count":3,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/posts\/770\/revisions"}],"predecessor-version":[{"id":88118,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/posts\/770\/revisions\/88118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/media\/88005"}],"wp:attachment":[{"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/media?parent=770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/categories?post=770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ampac1.com\/blog\/wp-json\/wp\/v2\/tags?post=770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}