{"id":1209,"date":"2019-08-01T02:08:35","date_gmt":"2019-08-01T02:08:35","guid":{"rendered":"https:\/\/www.ampac1.com\/blog\/assessing-the-threats-of-organophosphate-esters-flame-retardants-and-plasticizers-to-drinking-water-safety-based-on-usepa-oral-reference-dose-rfd-and-oral-cancer-slope-factor-sfo\/"},"modified":"2026-05-03T20:22:10","modified_gmt":"2026-05-04T03:22:10","slug":"assessing-the-threats-of-organophosphate-esters-flame-retardants-and-plasticizers-to-drinking-water-safety-based-on-usepa-oral-reference-dose-rfd-and-oral-cancer-slope-factor-sfo","status":"publish","type":"post","link":"https:\/\/www.ampac1.com\/blog\/assessing-the-threats-of-organophosphate-esters-flame-retardants-and-plasticizers-to-drinking-water-safety-based-on-usepa-oral-reference-dose-rfd-and-oral-cancer-slope-factor-sfo\/","title":{"rendered":"Assessing the threats of organophosphate esters (flame retardants and plasticizers) to drinking water safety based on USEPA oral reference dose (RfD) and oral cancer slope factor (SFO)"},"content":{"rendered":"<p><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau1\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Jiafu<\/span><span class=\"text surname\">Li<\/span><span id=\"baff1\" class=\"author-ref\"><sup>a<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau2\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Jiahui<\/span><span class=\"text surname\">He<\/span><span id=\"baff1\" class=\"author-ref\"><sup>a<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau3\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Yuna<\/span><span class=\"text surname\">Li<\/span><span id=\"baff2\" class=\"author-ref\"><sup>b<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau4\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Yunqing<\/span><span class=\"text surname\">Liu<\/span><span id=\"baff3\" class=\"author-ref\"><sup>c<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau5\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Wenjie<\/span><span class=\"text surname\">Li<\/span><span id=\"baff3\" class=\"author-ref\"><sup>c<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau6\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Nan<\/span><span class=\"text surname\">Wu<\/span><span id=\"baff3\" class=\"author-ref\"><sup>c<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau7\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Lifen<\/span><span class=\"text surname\">Zhang<\/span><span id=\"baff2\" class=\"author-ref\"><sup>b<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau8\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Ying<\/span><span class=\"text surname\">Zhang<\/span><span id=\"baff2\" class=\"author-ref\"><sup>b<\/sup><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#!\" name=\"bau9\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"content\"><span class=\"text given-name\">Zhiguang<\/span><span class=\"text surname\">Niu<\/span><\/span><\/a>\\n<\/p>\n<h2 class=\"section-title u-h3 u-margin-l-top u-margin-xs-bottom\">Abstract<\/h2>\n<p>\\n<\/p>\n<div id=\"abssec0010\">\\n<\/p>\n<p id=\"abspara0010\">Organophosphate esters, or OPEs, are a big concern. These compounds, used as flame retardants and <a title=\"Learn more about Plasticizer from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/plasticizer\" rel=\"nofollow noopener\" target=\"_blank\">plasticizers<\/a>, are emerging <a title=\"Learn more about Contaminant from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/contaminant\" rel=\"nofollow noopener\" target=\"_blank\">pollutants<\/a>, and their threat to <a href=\"https:\/\/www.ampac1.com\/blog\/drinking-water-nitrate-and-cancer-risk-a-systematic-review-and-meta-analysis\/\" &quot;Learn more about>drinking<\/a>-water-at-a-drinking-water-treatment-plant-using-uv-and-chlorine-dioxide-disinfection\/&#8221;>water<\/a>-and-distribution-system-in-an-unchlorinated-drinking-water-system-by-sourcetracker-using-microbial-community-fingerprints\/&#8221;>drinking<\/a> Water from ScienceDirect&#8217;s AI-generated Topic Pages&#8221; href=&#8221;https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/drinking-water&#8221;>drinking water<\/a> safety isn&#8217;t widely known. Now, the USPEA has updated the oral reference dose (RfD) and oral cancer slope factor (SFO) for OPEs. This means we can actually assess how dangerous OPEs are in our <a href=\"https:\/\/www.ampac1.com\/blog\/drinking-water-nitrate-and-cancer-risk-a-systematic-review-and-meta-analysis\/\">drinking water<\/a>. <\/p>\n<p>\\n<\/p>\n<p>This study looked at OPEs in drinking water across 79 cities in China. These cities represent 28.8% of China&#8217;s population and 44.1% of its <a title=\"Learn more about Gross Domestic Product from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/gross-domestic-product\" rel=\"nofollow noopener\" target=\"_blank\">GDP<\/a>. We found that the total concentration of 14 common OPEs in drinking water ranged from 13.42 to 265.48 nanograms per liter. While drinking water exposure was much lower than eating contaminated food, it was about the same as breathing in dust or skin contact. <\/p>\n<p>\\n<\/p>\n<p>Our health assessment showed a potential <a title=\"Learn more about Cancer Risk from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/cancer-risk\" rel=\"nofollow noopener\" target=\"_blank\">cancer risk<\/a> from OPEs in drinking water, with levels exceeding 1.00E-6. However, we didn&#8217;t see any obvious non-cancer effects, with levels below 1. Tris-(2,3-dibromopropyl) <a title=\"Learn more about Phosphate from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/phosphate\" rel=\"nofollow noopener\" target=\"_blank\">phosphate<\/a> (TDBPP) was a major player, causing about 72.4% of the cancer risk. This means we should really keep an eye on TDBPP in future studies. <\/p>\n<p>\\n<\/p>\n<p>Interestingly, the presence and spread of OPEs in China&#8217;s drinking water lined up well with the Aihui-Tengchong Line. We also found that <a title=\"Learn more about Drinking Water Treatment from ScienceDirect&#039;s AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/drinking-water-treatment\" rel=\"nofollow noopener\" target=\"_blank\">drinking water treatment<\/a> technology (DWTT) plays a key role. Cities with advanced DWTT had much lower levels of total OPEs, halogeno-OPEs, and alkyl-OPEs in their drinking water compared to cities with conventional DWTT. Advanced treatment reduced cancer risk from OPEs by about 65.6% and non-cancer risk by 36.5%. With OPE consumption growing every year in China and globally, we need more studies to truly understand the environmental threat these compounds pose. What are we waiting for?<\/p>\n<p>\\n\\n<\/p><\/div>\n<p>\\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub<\/a>\\n\\nThe post <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0043135419300892?via%3Dihub#new_tab\" rel=\"nofollow noopener\" target=\"_blank\">Assessing the threats of organophosphate esters (flame retardants and plasticizers) to drinking water safety based on USEPA oral reference dose (RfD) and oral cancer slope factor (SFO)<\/a> appeared first on <a href=\"https:\/\/thefactsaboutwater.org\" rel=\"nofollow noopener\" target=\"_blank\">Facts About Water<\/a>.\\n\\nSource: Water Feed<\/p>\n","protected":false},"excerpt":{"rendered":"<p>As one group of emerging\u00a0pollutants, the threat of\u00a0organophosphate\u00a0esters (flame retardants and\u00a0plasticizers, OPEs) to\u00a0drinking water\u00a0safety is not well recognized.<\/p>\n","protected":false},"author":1,"featured_media":87938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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